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Exclusive: Jocasta Neuroscience raises $35M
Exclusive: Jocasta Neuroscience raises $35M for clinical development
Jocasta Neuroscience Lands $35 Million Series A
Jocasta Neuroscience Lands $35 Million Series A to Advance Longevity Protein Program for Managing Cognitive Impairment
CSF Klotho Levels Tied to Cognitive Function in Parkinson’s Disease
A 2024 study demonstrates that higher cerebrospinal fluid klotho levels correlate with better cognition in people with Parkinson’s, suggesting klotho may be a biomarker or therapeutic target.
KL-VS Variant Reduces Age-Related Inflammation and Synaptic Decline
This 2024 study reveals that carriers of the KL-VS variant exhibit lower levels of neuroinflammatory and synaptic degeneration markers, indicating a potential resilience mechanism against age-related cognitive decline.
Klotho Enhances Cognition in Aged Non-Human Primates
A 2023 Nature Aging study shows that low-dose klotho administration improves cognition in aging rhesus macaques, supporting translational potential for age-related cognitive decline in humans.
Lower Klotho Levels in APOE4 Carriers May Elevate Alzheimer’s Risk
This 2022 study finds that APOE4 carriers have lower serum klotho levels, helping explain increased Alzheimer’s vulnerability and offering insight into the gene-environment interaction in brain aging.
Klotho Variant Linked to Reduced Amyloid in APOE4 Carriers
This 2021 Neurobiology of Aging meta-analysis finds that carriers of the KL-VS genetic variant show reduced brain amyloid burden, especially in those with APOE4, suggesting a protective role in Alzheimer’s risk.
Peripheral Klotho Fragment Improves Brain Resilience in Aging and Parkinson’s Models
A 2017 study in Cell Reports shows that peripheral delivery of a klotho protein fragment enhances cognition and neural resilience in young, aging, and α-synuclein transgenic mice, despite not crossing the blood-brain barrier.
Klotho Improves Cognition in Alzheimer’s Mouse Model
This 2015 Journal of Neuroscience study demonstrates that systemic klotho treatment improves learning and memory in a mouse model of Alzheimer’s, revealing potential for neurodegenerative therapy.